Preclinical

Bespoke suite of in vivo services to advance therapeutics to clinic

Our Preclinical Services

Our bespoke in vivo services enable the advancement of preclinical endpoint studies from in-life testing through to histopathological analysis. Highly agile and tailored to specific scientific need, we cover a wide range of disease areas and therapeutic approaches.

What We Do

EVALUATE AND DEVELOP RELEVANT ANIMAL MODELS

  • Evaluate the mechanism bringing about the disease state, and their potential translatability
  • Anticipate interactions of potential therapeutic with model.
  • Review previous data and experience to inform approach
  • Engage with internal and external network of experts to guide selection
  • Source relevant existing or develop bespoke model to answer the scientific question
  • Generate or source, and characterise transgenic animals
  • Conduct pilot studies to determine performance of model in our hands

TEST AGENT PROFILING AND EFFICACY

  • Fully characterise potential therapeutics in vivo (PK/PD, tolerability, biomarker collection and analysis)
  • Optimisation of efficacy studies to increase translatability and confirm reproducibility
  • Enhance the relevant therapeutic range for the desired endpoints
  • Flexible, agile approach to study design, with in-life real-time decision-making
  • Access to state-of-the-art in vivo equipment across our network for a variety of in vivo readouts
  • Fully integrated in-life and ex vivo analysis within our biology and bioanalysis teams

Previous Programmes

Our Highly-talented team of scientists have experience spanning all elements of the drug discovery pathway in a wide range of disease areas and specialisms:

  • Oncology (xenograft, orthotopic, metastatic)
  • Inflammation (sepsis, lupus, osteoarthritis, IBD, renal disease, allergic asthma, rheumatoid arthritis, graft versus host disease)
  • Bleeding disorders (Haemophilia A and B, Glanzmann’s thrombasthenia)
  • Cardiovascular and metabolic (MASLD/MASH, pulmonary arterial hypertension, obesity, type 2 diabetes)
  • Fibrosis (idiopathic pulmonary fibrosis)
  • Neurological (stroke, neurodegeneration)

Our Histology Services

Bespoke staining to answer model- and target-specific questions.

Our bespoke capabilities enable the advancement of standalone or preclinical endpoint study through histopathological analysis. Cell type markers, cell turnover indicators and tinctorial stains can be incorporated into a customised panel to answer key questions.

What We Do

Sample processing

  • Expert dissection and necropsy skills
  • Conventional tissue processing such as FFPE or frozen
  • Production of high-quality microscope slides by cryotomy or microtomy

IMMUNOHISTOCHEMISTRY AND IMMUNOFLUORESCENCE

  • Large range of tinctoral stains such as haemotoxylin and eosin, periodic acid schiff’s (with or without amylase digestion), picrosirius red
  • Bespoke chromogenic and fluorescent IHC to label proteins of interest

EXPERT Analysis

  • Slides available digitally for dissemination
  • Independent consultant pathologist interpretation of slides, including morphometric analysis for in vivo model and target expression validation, disease profiling, compound efficacy assessment, and toxicology and safety evaluation.

RxCelerate offers a unique business model catering to both small molecules and biologics. We work with you to drive your asset through drug discovery, preclinical research and beyond.

Our combination of integrated teams and unique technologies allows RxCelerate to develop the optimal drug discovery strategy to deliver pharma-grade drug candidates quickly and at a fraction of the cost of traditional approaches.