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Phenome-wide association studies (PheWAS) investigate the non-hypothesis driven associations between variants of a single gene and a wide range of phenotypes, typically coincident with disease.

At RxCelerate, we use PheWAS for:

1. Target validation: To ascertain whether pharmacological modification in Man will have the expected effect.
2. Indication selection: Determining what is most likely to be amenable to modification of the target.
3. Toxicology: Enabling identification of candidate toxicity pathways that may be linked to the target; allowing focused target-specific investigations to be added to early stage clinical trials, reducing the risk of later (and more costly) failure.