HOME > SERVICES & CAPABILITIES > PheWAS
Phenome-wide association studies (PheWAS) investigate the non-hypothesis driven associations between variants of a single gene and a wide range of phenotypes, typically coincident with disease.
At RxCelerate, we use PheWAS for:
- Target validation: To ascertain whether pharmacological modification in Man will have the expected effect.
- Indication selection: Determining what is most likely to be amenable to modification of the target.
- Toxicology: Enabling identification of candidate toxicity pathways that may be linked to the target; allowing focused target-specific investigations to be added to early stage clinical trials, reducing the risk of later (and more costly) failure.