We are currently looking to recruit a computational modeller to expand our group. Computational design is at the forefront of our approach, driving projects with innovative methodologies and solving challenging problems for our clients. As part of our success and continued expansion, we are looking to add a new member to our in-silico discovery team.
The team designs both small molecules and biologics, often on completely novel targets, which require an appetite for the application and development of innovative methods to achieve project goals.
In the role of computational chemist or protein modeller you will be involved in a variety of scientific activities and will have a significant degree of input into any project you work on. It is important that you are self-motivated and have the determination to solve complex problems whilst working as part of team.
- You will ideally have a PhD or MSc with a chemistry background
- Ideally 3 years relevant experience; a drug discovery background gained within a pharmaceutical company or a CRO is preferred, however an academic only background with strong credentials in development and application of novel methods will also be considered.
- You will have carried out protein structure-based analysis and optimisation and be able to demonstrate real world outcomes from modelling
- You will be able to apply protein homology modelling procedures and understand applicability of relevant techniques and approaches, especially for sequences of low identity to structural template
- Use and proficiency of a programming language such as Python and libraries such as RDkit an advantage
- Excellent time management skills
- Excellent communication (both verbal and written) and organizational skills
- Proven ability to work as part of a team of people with diverse skills and scientific backgroundsand
- Use of MOE program and SVL language a significant advantage.
- Use of molecular dynamics using AMBER, GROMACS or NAMD and critical analysis of outputs and methodologies an advantage.
- Experience of alchemical methods an advantage
- Familiarity with HPC and implementation an advantage
- Experience of modelling membrane bound systems an advantageor
- ou will have hands-on experience of antibody modelling and understand what features of antibodies can be optimised using in silico techniques
- Use of Rosetta program a significant advantage
This is a challenging and rewarding role for which all applicants with an appropriate scientific background are encouraged to apply.
RxCelerate offers a competitive salary with an annual bonus scheme and company benefit package.
When applying for this role, please include a cover letter outlining how you meet the competencies described above. Interested applicants should send a cover letter and curriculum vitae in PDF format to email@example.com by Monday 8th March.
Informal enquires can also be directed to this email address. Applicants must be eligible to work in the UK. No agencies please.